Emerin-prelamin A interplay in human fibroblasts
نویسندگان
چکیده
منابع مشابه
Different prelamin A forms accumulate in human fibroblasts: a study in experimental models and progeria
Lamin A is a component of the nuclear lamina mutated in a group of human inherited disorders known as laminopathies. Among laminopathies, progeroid syndromes and lipodystrophies feature accumulation of prelamin A, the precursor protein which, in normal cells, undergoes a multi-step processing to yield mature lamin A. It is of utmost importance to characterize the prelamin A form accumulated in ...
متن کاملThe molecular basis of emerin-emerin and emerin-BAF interactions.
Emerin is a conserved membrane component of nuclear lamina structure. Here, we report an advance in understanding the molecular basis of emerin function: intermolecular emerin-emerin association. There were two modes: one mediated by association of residues 170-220 in one emerin molecule to residues 170-220 in another, and the second involving residues 170-220 and 1-132. Deletion analysis showe...
متن کاملIn vitro Co-Culture of Human Skin Keratinocytes and Fibroblasts on a Biocompatible and Biodegradable Scaffold
Background: Extensive full-thickness burns require replacement of both epidermis and dermis. In designing skin replacements, the goal has been to re-create this model and make a product which has both essential components. Methods: In the present study, we developed procedures for establishing confluent, stratified layers of cultured human keratinocytes on the surface of modified collagen-chito...
متن کاملEmerin organizes actin flow for nuclear movement and centrosome orientation in migrating fibroblasts
In migrating fibroblasts, rearward movement of the nucleus orients the centrosome toward the leading edge. Nuclear movement results from coupling rearward-moving, dorsal actin cables to the nucleus by linear arrays of nesprin-2G and SUN2, termed transmembrane actin-associated nuclear (TAN) lines. A-type lamins anchor TAN lines, prompting us to test whether emerin, a nuclear membrane protein tha...
متن کاملP-130: Piwil2 Reprograms Human Fibroblasts to Germ Cell Lineage
Background The piwi family genes are highly conserved during evolution and play a crucial role in stem cell self-renewal, gametogenesis, and RNA interference in diverse organisms ranging from Arabidopsis to humans. Piwil2, also known as Hili, is one of the four human homologues of piwi. Piwil2 was found in germ cells of adult testis, suggesting that this gene functions in spermatogonial stem ce...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biology of the Cell
سال: 2009
ISSN: 0248-4900
DOI: 10.1042/bc20080175